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How to have longer and healthy lifespan interview with professor Mirisola about the Fasting Mimicking Diet

How to have longer and healthy lifespan: interview with professor Mirisola about the Fasting Mimicking Diet

Live longer and healthier

The concept of “living longer and healthier”, which nowadays, given the increased risk of pathologies, seems to be unachievable, is based on the always more certain conviction that nutrition contributes to its realization.

Science has certainly improved qualitatively human life, both through the introduction of new technologies, in the fields of biology and medicine.

Is it possible to live longer and healthier through nutrition? Professor Mirisola explains how!

Professor Mario Mirisola, an illustrious professor of biology and genetics at the University of Palermo, has deepened his studies on the genetics of longevity. Thanks to his many skills, he actively participated in the research project of Professor Valter Longo and collaborated in what is now known as the Fasting Mimicking Diet (FMD).

Professor Mirisola can you tell us when and how did you start working with Valter Longo?

“I met Longo in 2007 after winning a Fulbright grant from the US State Department. During my career, I have always shown interest and curiosity for all these factors that can affect lifespan. It is surprising to discover how a caloric restriction (CR) and an appropriate lifestyle can be the main promoter of longevity and thus contribute to “living longer and healthier”. I therefore considered his laboratory as one of the most promising in the field of longevity research”.

Today, it seems that the thesis that our health is somehow related to food is always more confirmed. So, is it wise to talk about food that help us “live longer and healthier?”

“Absolutely! Hippocrates had already imagined that if we gave to the sick food they needed, we would be able to cure all diseases. The idea that there is a close correlation between our state of health and a correct diet is not new. Recently, however, many of the details that have found out have allowed us to study more thoroughly the metabolic pathways that are activated and extinct in our bodies by individual nutrients (molecular nutrition). This discovery could therefore allow us to live longer and in better health”.

So, could the correction of our eating habits help us prevent chronic non-transmissible diseases?

“Yes, for example, certain conditions increase the risk of developing chronic degenerative diseases such as hypercholesterolemia or insulin resistance. These conditions are strongly associated with the development of different types of pathologies (cardiovascular, tumours, diabetes), which can be corrected and reduced very efficiently by regulating nutrition “.

Professor, as mentioned earlier, you have contributed to the research project on the Fasting Mimicking Diet … We would like to have your opinion:

“The FMD is extremely effective, the improvements obtained are surprising, both in the general population and in patients suffering from many pathologies. Blood glucose, cholesterol, blood pressure and body mass index decrease in all subjects, but especially in those who particularly have high values”.

As an expert in medical genetics, what results have been highlighted?

“From the molecular point of view, there is a hormonal reorganization with the decrease of a key hormone that promotes the mechanisms of aging, IGF-1. We also know that there is an important response to the Fasting Mimicking Diet, not only coming from the immune system but also from the stem cells, which brings about a kind of tissue regeneration. Scientific research shows that, thanks to nutrition, the concept of living longer and healthier could be achievable. ”

You followed and guided many people through this trip. It would be interesting to know the results of a pathology…

“During the 5 days provided by ProLon® Fasting Mimicking Diet, I monitored the values ​​of different patients with important conditions such as cancer. What I could find in these subjects was a more positive response to chemotherapy treatments. Let me explain you: reactions to the toxicity of chemotherapy are additive that is to say, as the cycles go ahead, side effects increase; who had already done several cycles of chemotherapy had a higher toxicity. After the FMD, the inflammation and toxicity values ​​have considerably reduced! Do you want to know what the most common comment was? “If only I had done it before.”

Can FMD help treat some diseases?

“Clinical trials and research are still ongoing, but the results so far suggest that these, combined with traditional treatments, can bring benefits and allow us to live longer and healthier. I’d like to emphasize that not everyone can take part in the protocol, especially in the presence of pathologies, an authorization from your doctor/specialist is necessary and for some, it could be contraindicated “.

What is the perspective of the Fasting Mimicking Diet the in combination with the traditional therapies currently used for the treatment of pathologies?

“For tumours and other diseases such as multiple sclerosis, the results are very positive. Currently, we cannot draw definitive conclusion, the available figures are still low, but research keeps going on. Among the effects, there is also a decrease of the C-reactive protein, an indicator of the state of inflammation of our body. Improving these parameters suggests that FMD can be very effective in improving health or preventing chronic degenerative diseases. We expect this to have a major impact on health. We are currently starting a clinical trial on subjects with a high genetic risk of developing breast and ovarian cancer, so we hope to be able to say more about the effects of this nutritional approach in the coming months on preventing the onset of diseases “.

Professor, the number of people who go on diet with DIY methods is growing more and more! What is your opinion on this choice…?

“In general, it’s not a good idea. During the different phases of the day, the distribution between macronutrients is important. In the ProLon® kit, the balance between macro and micronutrients, minerals and vitamins is the result of a scientific logic and thus guarantees its effectiveness. The kit greatly simplifies the task and makes it more reproducible, precisely because it is tested on a very large number of people.

What would you recommend?

“DIY fasting is not impossible, but not being experts in the field can lead to disasters in general, and may involve a deficiency for some substances, or too much for others. I therefore recommend that you always consult a nutritionist who knows the FMD argument and who does not improvise.

We conclude with three adjectives to describe the Fasting Mimicking Diet:

  • Effective
  • Healthy
  • Surprising

Article written by: Francesca Florenzo

Caloric Restriction, The 5 Days Of Lucia

Caloric Restriction: The 5 Days of Lucia

When it comes to deal with something new, doubts and questions that arise are numerous and often come with a kind of scepticism. In order to remove these doubts, at least in part, telling you my personal experience could be useful. Lucia, is a 36-year-old homemaker and full-time mother, she is sharing with us her own experience of the 5-day caloric restriction provided by ProLon’s Fasting Mimicking Diet (FMD)!

Lucia, how did you know Pr. Longo?

“I was at home zapping on TV when an interview running on a channel on the show” le Iene“caught my attention.
They were talking about a certain 5-day diet designed by a scientist. Before that time, I had never heard of Professor Longo. So, intrigued by the subject treated in this famous interview, I did some research. After getting more information and understanding that it was not about a common slimming diet, I decided to contact you.’’

Is this the first time you have been on a calorie restriction?

“In the past, I followed diets aiming at losing weight. One of the reasons I decided to follow this type of dietary approach is precisely because it has a very different purpose. I have been suffering bowel issues for a year and a half. Food intolerance has led me to exclude certain types of food, and I must admit that it has been tough to me because I am a “hearty eater”. I did not imagine that it could be a food protocol enabling the body reset, so I thought, “why not try it”.

Did you have any particular difficulty following the diet with the kit?

“No, I must say it is easy to use. It was exactly what I was looking for: something schematic that dictated what to do and how. Of course, the mind-set is important, but having something structured day after day is a fundamental help!”

Please, describe us your 5 days

“The first day, I did not feel anything particular, the 2nd, 3rd and 4th I had a strange headache, but nothing unbearable, I do not know, I would define it more like a “feeling of tiredness”. In addition, the first nights, I was a little tired. The last day, I had some issues to eat the preparations, but only for a matter of taste!”

Have you been very hungry during these days?

“Honestly, not during the day. Only in the evening I was a bit hungry, especially when I had to cook for my family, it is very hard to resist the temptations, but luckily, the desire to follow scrupulously this program was stronger and I did not give up.”

Considering that it is very subjective, which are the preparations that you have most appreciated among all the preparations?

“The bars and the olives were very tasty, but what I liked the most was the minestrone, a good flavor, I would say!”

 What did you dislike?

“The tomato soup, on the fifth day I could not appreciate the taste. I did not like the kale cracker either.”

Let’s talk about the results:

“The first obvious factor is the decrease of the abdominal circumference. I have lost more or less 2 kg. Besides, you feel more energetic and your ability to focus seems to have improved a lot. I also had a positive return in my daily life. Let me explain, before I used to dislike vegetables and I did not drink liquids during the day, now I have integrated vegetables and I drink at least 1.5 litter of water during the day”.

What is about the problems you mentioned at the beginning of the interview?

“It was the most surprising result. Since I started this diet, I do not have intestinal problems anymore, I can finally eat dairy products, I do not know what kind of correlation is there, but I am very enthusiastic. In January, after Christmas holidays, I absolutely want to do it again! ”

Three adjectives to describe the fasting mimicking diet

  • Surprising
  • Useful
  • Well studied


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